This thesis presents a method for reliably and robustly producing samples of amyloid- A by capturing them at various stages of aggregation as well as the results of subsequent imaging with various atomic force microscopy AFM methods all of which add value to the... Lees meer.

This volume describes the discovery and development history of the most promising drugs now in development for combating Alzheimer s disease. Alzheimer s disease is the most prevalent neurodegenerative disorder in the elderly. A recent study from the Bloomberg School o... Lees meer.

Assembly and deposition of physiologically generated amyloidogenic proteins occur in various human diseases referred to as amyloidoses through misfolding that is either partial unfolding or partial folding of the proteins. A growing body of evidence suggests that mis... Lees meer.

Prions are infectious proteins best known as the agent of BSE and new variant Creutzfeldt-Jakob disease. Their infectious form has been identified as a beta-sheet-rich molecular aggregate termed amyloid fibril. Additionally amyloid formation is eponymous for a group of... Lees meer.

This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer s disease and other amyloid diseases indicated also by the earlier book in the series Volume 38 devot... Lees meer.

A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology pathogenesis diagnosis and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors oli... Lees meer.

Markov State Models MSM sind der Goldstandard zur Modellierung biomolekularer Dynamik da sie die Identifizierung und Analyse metastabiler Zust nde erm glichen. Markov State Models MSM sind der Goldstandard zur Modellierung biomolekularer Dynamik da sie die Ident... Lees meer.

The second edition of this text presents an overview of the most recent developments in this area including clinical presentation etiology pathogenesis and differential diagnosis. The rationale for various therapies including transplantation is discussed and tissue... Lees meer.

... Lees meer.

Due to the unstable noncrystalline and insoluble nature of some proteins the technologies such as X-ray crystallography NMR nuclear magnetic resonance spectroscopy and dual polarization interferometry etc sometimes cannot produce the 3D structures of these proteins... Lees meer.

Peptide Catalysts including Catalytic Amyloids Volume 697 in this esteemed series highlights new advances in the field with this new volume presenting interesting topics on Screening of oxidative behaviors in catalytic amyloid assemblies Catalytic amyloids derived... Lees meer.

A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology pathogenesis diagnosis and therapy of amyloid diseases. In recent years various in vitro and in vivo techniques transgenic technologies and... Lees meer.

This third edition volume expands on the previous editions with many new chapters that cover the latest techniques and topics that were not addressed in the previous volumes. The chapters in this book are divided into three parts. Part One covers in vitro assays that f... Lees meer.

This detailed volume focuses on methods for the characterization of aggregation processes that lead to the formation of amyloid fibrils and amyloid oligomers which feature in the etiology of a variety of human disorders collectively known as amyloidoses. This detai... Lees meer.

This authoritative volume contains 179 chapters by international experts on recent developments in our understanding of amyloid proteins protein folding disorders and new and proposed clinical trials in amyloidosis. Topics include detection and characterization techn... Lees meer.