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New Strategies Targeting Cancer Metabolism. Anticancer Drugs Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites. antifolates purines and pyrimidines the main classes of antimetabolites which ar... Lees meer.

This exciting new book presents the first comprehensive overview of clinical trials of camptothecins a new class of anticancer agents. Camptothecins are synthetic and semisynthetic derivatives of a plant alkaloid that inhibit a cellular enzyme and trigger a cascade of... Lees meer.

Offering an authoritative and timely account by twenty-nine internationally recognized experts Metal Ions in Biological Systems. Metal Complexes in Tumor Diagnosis and as Anticancer Agents is devoted solely to the vital research area concerning metal complexes in canc... Lees meer.

This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene NHC ligands wh... Lees meer.

Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series copmrising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The first volume presents reviews of many classes of... Lees meer.

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Proceedings of the 18th Annual Detroit Cancer Symposium Detroit Michigan USA June 13-14 1986... Lees meer.

Medicinal Chemistry of Chemotherapeutic Agents. A Comprehensive Resource of Anti-infective and Anti-cancer Drugs focuses on the basics and fundamentals of chemistry involved in chemotherapeutic agents. Each chapter comprises distinct chemical classifications that inclu... Lees meer.

Dihydropyrimidinones as Potent Anticancer Agents gives readers a unique update on scientific knowledge accomplishments and recent advances in the medicinal chemistry of dihydropyrimidinones in cancer treatment. Dihydropyrimidinones are known to be active scaffold and h... Lees meer.

The work presented in the Book is aimed at the synthesis of new heterocycles containing active s-triazine moiety styryl moieties. The prepared heterocyclic compounds were characterized by spectral studies and were screened for their anticancer and anti-HIV activities... Lees meer.

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons but it nevertheless may become a drug thr... Lees meer.

This book is focused on molecular modeling using both structure based and ligand based design followed by synthesis of potential anticancer agents. Heat shock protein 90 and Cyclin dependent kinase 1 are used as a valid target for developing anticancer agents. Cyclin de... Lees meer.

Metal-based anticancer drugs are among the most successful therapeutic agents as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery... Lees meer.

In the present investigation novel pyrazoles and pyrrolo 3 2-c pyridines have been designed as potential antiproliferative agents against different types of cancer. Their antiproliferative activities were examined against 61 cancer cell lines of 9 different cancer type... Lees meer.