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Springer theses total synthesis of indole alkaloids


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This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide.

The book first describes the total and formal synthesis of dictyodendrins A–F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine.

These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compounds.





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Product specificaties:

Taal: en

Bindwijze: E-book

Oorspronkelijke releasedatum: 18 september 2020

Ebook Formaat: -607848

Illustraties: Nee

Hoofdauteur: Junpei Matsuoka

Hoofduitgeverij: Springer

Lees dit ebook op: Desktop (Mac en Windows)

Lees dit ebook op: Kobo e-reader

Lees dit ebook op: Android (smartphone en tablet)

Lees dit ebook op: iOS (smartphone en tablet)

Lees dit ebook op: Windows (smartphone en tablet)

Studieboek: Nee

EAN: 9789811586521