Wound healing properties of some indigenous ghanaian plants

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The work involves the investigation of 6 indigenous Ghanaian plants P. pinnata, H. opposita, G. arboreum, A. nobilis, F. asperifolia and B. aegyptiaca used for the treatment of bacterial infections and wounds. It also describes the isolation and characterization of the active principles from P. pinnata. Extracts were assessed for in vitro antibacterial activity, usingwild-type and resistant strains of Staph.aureus. P.pinnata, H. opposita, G. arboreum and F. asperifolia showed antibacterial activity. The active compounds in P. pinnata were isolated, using chromatographic techniques and identified with the aid of NMR spectroscopy. The wound healing action of the plant extracts were assessed using in vitro models. P.pinnata, G. arboreum and F. asperifolia at concentrations from 1 to 25ug/ml had a significant stimulatory effect on the proliferation of HDF (142BR) cells. Paullilupeol and paullilupeone isolated from P. pinnata, showed a dose-dependent increase in proliferation of the up to 3uM. All extracts at concentrations 1 to 50ug/ml, had a statistically significant antioxidant protective effect against hydrogen peroxide induced damage to 142BR cells."

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Oorspronkelijke releasedatum: 25 januari 2011

Aantal pagina's: 224

Hoofdauteur: Kofi Annan

Hoofduitgeverij: Lap Lambert Academic Publishing

Product breedte: 152 mm

Product hoogte: 13 mm

Product lengte: 229 mm

Verpakking breedte: 152 mm

Verpakking hoogte: 13 mm

Verpakking lengte: 229 mm

Verpakkingsgewicht: 336 g

EAN: 9783843371698

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