Several pressures have accelerated the search for more environmentally and toxicologically safe and efficacious pesticides. Most commercially successful pesticides have been discovered by screening compounds synthesized in the laboratory for pesticidal properties. The increasing incidence of pesticide resistance is also fueling the need for new pesticides. Furthermore, most synthetic chemicals pesticides are halogenated hydrocarbons with relatively long environmental half-lives and more suspect toxicological properties than most natural compounds. Thus, natural compounds have increasingly become the focus of those interested in discovery of safety pesticides.Most people believe that natural pesticides are safer and more Eco-friendly than man-made pesticides Thousands of the plant secondary compounds have been identified as natural pesticides.Natural pesticides will always be around, but people needed to smart up regarding their use and effectiveness.This contributes with a useful background of the exploitation of plant-derived pesticides, highlights possibilities and limitations and gives guidance for future work.