Formulation of fast dissolving tablets of phenylephrine hydrochloride

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Recent advances in novel drug delivery system aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach is fast dissolving tablets (FDT) of Phenylephrine Hydrochloride, a selective 1 adrenergic receptor antagonist, used for nasal decongestant and producing mydriasis effect. In present work an attempt has been made by formulating fast dissolving tablets of Phenylephrine Hydrochloride by superdisintegrants addition method using croscarmellose sodium, crospovidone and sodium starch glycolate. A total of 10 batches were prepared by using various combination and concentration of superdisintegrants and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release studies, kinetic studies and stability studies. Amongst all the formulations F2 and F9 were found to be better formulations which include single superdisintegrants and combination of superdisintegrants. Finally it was concluded that FDT of Phenylephrine Hydrochloride will be used as a novel drug dosage form for pediatrics and geriatrics."

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Oorspronkelijke releasedatum: 15 februari 2013

Aantal pagina's: 148

Hoofdauteur: Chapla Nikunj

Tweede Auteur: Pujara Naisarg

Co Auteur: Pujara, Naisarg

Hoofduitgeverij: Lap Lambert Academic Publishing

Product breedte: 152 mm

Product hoogte: 9 mm

Product lengte: 229 mm

Verpakking breedte: 152 mm

Verpakking hoogte: 9 mm

Verpakking lengte: 229 mm

Verpakkingsgewicht: 227 g

EAN: 9783659346040

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