Formulation and evaluation of albendazole tablet

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The objective of this research work was to formulate and evaluate the floating drug delivery system containing Albendazole, an anthelmintic drug, using different polymers and to optimize the best formulation. Different excipients were tested for their compatibility with Albendazole by the FTIR studies. Present study has demonstrated the successful utilization of technique of FT IR to assesst he compatibility of Albendazole with the excipients used in the development of floating drug delivery system of Albendazole. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with Albendazole which were then used in the preparation of Albendazole floating tablets. Albendazole tablets were prepared by wet granulation technique using HPMC, HPMC K4M and chitosan as polymers, stearic acid, citric acid, lactose and gas generating agent such as sodium bicarbonate were taken as independent variables. It was then evaluated by using USP-II (Paddle) apparatus containing 0.1 N HCl as a dissolution media. The release mechanisms of Albendazole from floating tablet were evaluated by the n value of Krosmeyer Peppas model.

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Oorspronkelijke releasedatum: 23 juli 2012

Aantal pagina's: 120

Hoofdauteur: Sandhya Chaurasia

Tweede Auteur: Anshuli Sharma

Co Auteur: Vasireddy, Suneel kumar

Hoofduitgeverij: Lap Lambert Academic Publishing

Product breedte: 152 mm

Product hoogte: 7 mm

Product lengte: 229 mm

Verpakking breedte: 152 mm

Verpakking hoogte: 7 mm

Verpakking lengte: 229 mm

Verpakkingsgewicht: 186 g

EAN: 9783659192920

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