Formulation and evaluation of floating in situ gel of levetiracetam

Rubriek: Textual/Printed/Reference Materials - Boek

Prijs: € 57.99

Rating: 0/5

☆

☆

☆

☆

☆

Verzending:
Uiterlijk 5 februari in huis

The aim of this study was to develop a new intra-gastric oating in situ gelling system for controlled delivery of levetiracetam for the treatment of partial onset seizures.High dose of levetiracetam (750 to 1000 mg) is di cult to incorporate in oating tablets but can easily be given in liquid dosage form. Sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which drug and calcium carbonate were added. A 32 full factorial design was used for optimization. The concentrations of sodium alginate (X1) and calcium carbonate (X2) were selected as the independent variables.The amount of the drug released after 1 h (Q1) and 6 h (Q6) and 12 h (Q12), viscosity and Floating lag time of the liquid formulation were selected as the dependent variables. The studies indicate that the formulation was effective in providing in vitro release for extended time up to 12 hrs and also convenient for geriatric and paediatric patient and increase drug residency to the GIT."

• 1 Bekijk alle specificaties

Oorspronkelijke releasedatum: 14 juni 2012

Aantal pagina's: 132

Hoofdauteur: Miteshkumar Patel

Tweede Auteur: Kanu Patel

Co Auteur: Patel, Natvarlal

Hoofduitgeverij: Lap Lambert Academic Publishing

Product breedte: 152 mm

Product hoogte: 8 mm

Product lengte: 229 mm

Verpakking breedte: 152 mm

Verpakking hoogte: 8 mm

Verpakking lengte: 229 mm

Verpakkingsgewicht: 204 g

EAN: 9783659157646

---