Lc ms in drug bioanalysis
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This book covers the various methods of validation for high performance liquid chromatography - mass spectrometry (LC-MS) analytical techniques and their applications in the analysis of a broad range of drugs in modern clinical pharmacology.
High performance liquid chromatography – mass spectrometry (LC-MS) combines the separation power of liquid chromatography with the high sensitivity and selectivity of mass spectrometry. Therefore, LC-MS becomes the method of choice for drug bioanalysis in therapeutic drug monitoring, toxicology, and drug discovery and development. LC-MS in Drug Bioanalysis offers discussions on:
● LC-MS/MS method development and validation in a regulated environment
● Internal standard use in LC-MS/MS bioanalysis
● Pitfalls of LC-MS/MS and how to overcome them
● Dried blood spot sampling
● Microflow LC-MS/MS
● LC-MS/MS in therapeutic drug monitoring
● Applications of LC-MS/MS in drug bioanalysis
This book will aid readers to improve their skills in LC-MS/MS method development, validation, and applications in the analysis of drugs and their metabolites in complex biological matrices. In addition, this book provides detailed information on the bioanalysis of antidepressants, antipsychotics, steroid hormones, anticancer agents, and drugs of abuse. Newer methodologies are discussed including the use of unique sample preparation techniques and the implementation of imaging mass spectrometry in the localization of drug and drug metabolites in tissues.
Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.
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Taal: en
Bindwijze: Hardcover
Oorspronkelijke releasedatum: 16 juli 2012
Aantal pagina's: 484
Illustraties: Nee
Hoofdredacteur: Q. Alan Xu
Tweede Redacteur: Timothy L. Madden
Co Redacteur: Q. Alan Xu
Hoofduitgeverij: Springer
Editie: 2012 ed.
Extra groot lettertype: Nee
Product breedte: 162 mm
Product hoogte: 33 mm
Product lengte: 241 mm
Studieboek: Nee
Verpakking breedte: 162 mm
Verpakking hoogte: 33 mm
Verpakking lengte: 241 mm
Verpakkingsgewicht: 852 g
EAN: 9781461438274