Gelrite based in situ gel for the nasal delivery

Rubriek: Textual/Printed/Reference Materials - Boek

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Uiterlijk 5 februari in huis

Salbutamol sulfate (SS), a direct acting sympathomimetic; used for the treatment of acute and chronic asthma, was formulated as gelerite(r) in-situ gels. SS in-situ gels (2% w/w) were prepared at concentration of gellan gum 0.2%, 0.4% and 0.8% w/v with methyl paraben (0.05%) as preservative. In-vitro release in simulated nasal fluid showed relatively fast release and release kinetics followed diffusion kinetic model. In-vivo mucoadhesiveness test performed in rats, showed prolonged mucociliary transport time from 5 min (control solution) to 16.5 and 19.5 minutes for formulations containing 0.4% & 0.8% respectively. In-situ gels have demonstrated an adequate safety to the nasal mucosa of rats. The 0.4 % in-situ gel remained liquid for 6 months without occurrence of turbidity or gelation at storage temperature conditions. Statistical analysis revealed non-significant difference in content uniformity or release compared to the fresh ones. In-situ gel is a promising approach for the intranasal delivery of SS, combines the advantage of a solution, administration convenience and exact dosing with favorable residence time and expected improved drug absorption. .

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Salbutamol et Performance

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Le but de ce travail a ete d etudier les repercussions ergogeniques hormonales et metaboliques d une prise orale aigue 4 mg et chronique 12 mg jour pendant 3 4 semaines de salbutamol chez des volontaires sains de sexe masculin et feminin sedentaires et entraines au cours d exercices supramaxim Uiterlijk 5 februari in huis .. MEER INFO