This issue of Veterinary Clinics: Equine Practice, guest edited by Dr. Ramiro Toribio in collaboration with Consulting Editor Dr. Thomas Divers, is devoted to Diseases of Donkeys and Mules. Topics include:Endocrine and metabolic disorders of donkeys;Gastrointestinal disorders of donkeys and mules;Clinical pathology of donkeys;Genetics, evolution, physiology in donkeys/mules;Nutrition and malnutrition;Donkey and mule welfare;Dermatological disorders of donkeys/mules;Anesthesia, analgesia, and sedation in donkeys/mules;Dental disorders of donkeys;Clinical evaluation and preventative care of the donkey;Respiratory disorders of donkeys;Donkey and mule behavior;Clinical Pharmacology of donkeys;Key aspects of donkey and mule reproduction;and Foot Care and Practical Farriery for the Donkey.